2015–2016

23 September 2015

Noninvasive ventilation and intrapulmonary percussive ventilation

Posted in 2015–2016

Glenn Leemans Denise Daems and Wilfried De Backer

Chronic mucus hypersecretion (CMH) in, for example, chronic obstructive pulmonary disease (COPD) is associated with several poor outcomes such as reduced lung function and quality of life, increased frequencies of exacerbations and hospitalisations, and increased mortality [1]. Moreover, subjects with COPD and CMH are more likely to die of pulmonary infections than subjects without CMH [2]. Because of these poor associations, mucus clearance techniques have been of potential interest as a nonpharmacological treatment option [3]. The rationale behind these techniques is based on the exertion of an optimal expiratory airflow velocity that applies shearing forces to sputum at the air– liquid interface [4]. Airflow velocity could be manipulated by changes in airflow, lung volumes, pulmonary pressures and airway diameter [4, 5]. For example, autogenic drainage uses a balanced expiratory flow at different lung volumes to achieve the highest air velocity possible without causing airway compression to mobilise the secretions [6].

23 September 2015

Ten top tips for respiratory entrepreneurs

Posted in 2015–2016

Vivienne Parry

You've got a great idea that you're itching to get out there, but what turns that idea into a product used by clinical teams across Europe? Science writer Vivienne Parry talked to three former Product of Outstanding Interest finalists to get their top tips for success.